The Relationship Between {beta}-Cell Function and Glycated Hemoglobin

Sysop · February 24th, 2011, 02:48 AM

OBJECTIVEThe study objective was to assess the relationship between β-cell function and HbA1c.
RESEARCH DESIGN AND METHODSA total of 522 Mexican American subjects participated in this study. Each subject received a 75-g oral glucose tolerance test (OGTT) after a 10–12-h overnight fast. Insulin sensitivity was assessed with the Matsuda index. Insulin secretory rate was quantitated from deconvolution of the plasma C-peptide concentration. β-Cell function was assessed with the insulin secretion/insulin resistance (IS/IR) (disposition) index and was related to the level of HbA1c.
RESULTS
At HbA1c levels 5.5%, there was a precipitous decrease in both the Matsuda index and the IS/IR index. Subjects with HbA1c = 6.0–6.4% had a 44 and 74% decrease in the Matsuda index and the IS/IR index, respectively, compared with subjects with HbA1c

February 24th, 2011, 02:48 AM	#1
Sysop Administrator Join Date: Apr 2008 Posts: 83	The Relationship Between {beta}-Cell Function and Glycated Hemoglobin OBJECTIVEThe study objective was to assess the relationship between β-cell function and HbA1c. RESEARCH DESIGN AND METHODSA total of 522 Mexican American subjects participated in this study. Each subject received a 75-g oral glucose tolerance test (OGTT) after a 10–12-h overnight fast. Insulin sensitivity was assessed with the Matsuda index. Insulin secretory rate was quantitated from deconvolution of the plasma C-peptide concentration. β-Cell function was assessed with the insulin secretion/insulin resistance (IS/IR) (disposition) index and was related to the level of HbA1c. RESULTS At HbA1c levels 5.5%, there was a precipitous decrease in both the Matsuda index and the IS/IR index. Subjects with HbA1c = 6.0–6.4% had a 44 and 74% decrease in the Matsuda index and the IS/IR index, respectively, compared with subjects with HbA1c