High-Normal Serum Uric Acid Increases Risk of Early Declining Renal Function In Type

Sysop · March 24th, 2010, 12:07 AM

AbstractObjective:We previously described cross-sectional association between serum uric acid (UA) and reduced glomerular filtration rate (GFR) in non-proteinuric patients with type 1 diabetes. Here we prospectively investigated whether baseline UA impacts the risk of early Declining Renal Function (early DRF) in these patients.
Research Design and Methods:Patients with elevated urinary albumin excretion (n=355) were followed for 4-6 years for changes in urinary albumin excretion and GFR. The changes were estimated by multiple determinations of albumin to creatinine ratios (ACR) and serum cystatin C (GFRcystatin).
Results:
At baseline the medians (25th, 75th percentiles) for UA, ACR, and GFRcystatin values were 4.6 mg/dl (3.8,5.4), 26.2 mg/g (15.1, 56.0) and 129 ml/min/1.73 m2 (111,145), respectively. During the 6 year follow-up, significant association (p

March 24th, 2010, 12:07 AM	#1
Sysop Administrator Join Date: Apr 2008 Posts: 83	High-Normal Serum Uric Acid Increases Risk of Early Declining Renal Function In Type AbstractObjective:We previously described cross-sectional association between serum uric acid (UA) and reduced glomerular filtration rate (GFR) in non-proteinuric patients with type 1 diabetes. Here we prospectively investigated whether baseline UA impacts the risk of early Declining Renal Function (early DRF) in these patients. Research Design and Methods:Patients with elevated urinary albumin excretion (n=355) were followed for 4-6 years for changes in urinary albumin excretion and GFR. The changes were estimated by multiple determinations of albumin to creatinine ratios (ACR) and serum cystatin C (GFRcystatin). Results: At baseline the medians (25th, 75th percentiles) for UA, ACR, and GFRcystatin values were 4.6 mg/dl (3.8,5.4), 26.2 mg/g (15.1, 56.0) and 129 ml/min/1.73 m2 (111,145), respectively. During the 6 year follow-up, significant association (p