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Old February 12th, 2010, 12:05 AM   #1
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Default MD-Logic Artificial Pancreas System: A Pilot Study in Adults with Type 1 Diabetes Mel

Objective:Current state-of-the-art artificial pancreas systems are either based on traditional linear control theory or rely on mathematical models of glucose-insulin dynamics. Blood glucose control using these methods is limited due to the complexity of the biological system. The aim of this study was to describe the principles and clinical performance of the novel MD-Logic Artificial Pancreas (MDLAP) system.
Research Design and Method:The MDLAP applies fuzzy logic theory to imitate lines of reasoning of diabetes caregivers. It uses a combination of control to range and control to target strategies to automatically regulate individual glucose levels. Feasibility clinical studies were conducted in 7 adults with type 1 diabetes (age, 19-30 yr; mean diabetes duration, 10±4 yr; mean HbA1C, 6.6±0.7%). All underwent 14 full closed-loop control sessions of 8 hours (fasting and meal-challenge conditions) and 24 hours.
The mean peak postprandial (overall sessions) glucose level was 224±22 mg/dl. Postprandial glucose levels returned to below 180 mg/dl within 2.6±0.6 hours and remained stable in the normal range for at least one hour. During 24-hour closed-loop control, 73% of the sensor values ranged between 70-180 mg/dl, 27% were >180 mg/dl, and none were
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