Nontraditional Markers of Glycemia: Associations with microvascular conditions

Sysop · February 19th, 2011, 04:01 AM

OBJECTIVETo compare the associations of nontraditional (fructosamine, glycated albumin, 1,5-anhydroglucitol [1,5-AG]) and standard (fasting glucose, glycated HbA1c) glycemic markers with common microvascular conditions associated with diabetes mellitus.
RESEARCH DESIGN AND METHODSThere was a cross-sectional study of 1,600 participants (227 with a history of diabetes and 1,323 without) from the Atherosclerosis Risk in Communities (ARIC) Study, a community-based population. We conducted logistic regression analyses of the associations of diabetes-specific tertiles of fructosamine, glycated albumin, 1/(1,5-AG), fasting glucose, and HbA1c with prevalence of chronic kidney disease, albuminuria, and retinopathy after adjustment for demographic, clinical, and lifestyle variables.
RESULTS
We observed significant positive trends in the associations of each marker with albuminuria and retinopathy, even after accounting for demographic, clinical, and lifestyle factors (all P trends

February 19th, 2011, 04:01 AM	#1
Sysop Administrator Join Date: Apr 2008 Posts: 83	Nontraditional Markers of Glycemia: Associations with microvascular conditions OBJECTIVETo compare the associations of nontraditional (fructosamine, glycated albumin, 1,5-anhydroglucitol [1,5-AG]) and standard (fasting glucose, glycated HbA1c) glycemic markers with common microvascular conditions associated with diabetes mellitus. RESEARCH DESIGN AND METHODSThere was a cross-sectional study of 1,600 participants (227 with a history of diabetes and 1,323 without) from the Atherosclerosis Risk in Communities (ARIC) Study, a community-based population. We conducted logistic regression analyses of the associations of diabetes-specific tertiles of fructosamine, glycated albumin, 1/(1,5-AG), fasting glucose, and HbA1c with prevalence of chronic kidney disease, albuminuria, and retinopathy after adjustment for demographic, clinical, and lifestyle variables. RESULTS We observed significant positive trends in the associations of each marker with albuminuria and retinopathy, even after accounting for demographic, clinical, and lifestyle factors (all P trends